Antimicrobial natural products I
Antimicrobial peptides. cyclic lipopeptides…
Antimicrobial natural products II
- Terrestrial and marine organisms:
Antimicrobial substances from terrestrial and marine organisms. Essential oils. Bioactive phytochemicals. Plant/Herbal extracts…
Biocontrol. Biosynthesis of
Microbial-derived toxins. Bacteriocins (colicins, microcins, lantibiotics…). Archaeocins. Biocontrol approach to microbial invasions (probiotics, lactic acid bacteria…). Biosynthesis of antibiotics. Genetic and metabolic engineering. Gene regulation…
Phage therapy and biocontrol in humans, animals (agriculture-farm animals, aquaculture), plants, food industry…
Materials functionalization with bacteriophages. Using bacteriophages for microbiological detection...
Biofilm formation, control and eradication. Microbial adhesion to surfaces. Novel characterization techniques. Biofouling. Biofilms susceptibility to antimicrobials. Antibiotic resistance of microorganisms in biofilms. Genomics and Proteomics...
Antimicrobial materials science and surface chemistry. Antimicrobials in consumer products:
Antimicrobial, anti-adhesive surfaces & coatings.
Microbial adhesion to surfaces. Physical and chemical
(inorganic (e.g. silver, copper compounds) and organic)
surface modification. Cationic surfaces.
Functionalization strategies for polymers, metals, metal
ceramics. Drug-eluting concepts...
Antimicrobials in consumer products: Textiles (hygienic clothing, active wear, medical textiles…). Paper industry. Active packaging (food industry…). Safety and toxicological aspects…
Synthesis and screening of novel chemical compounds for antimicrobial action. Natural, synthetic and semi-synthetic antibiotics. Analogs. Structural determination.
In-silico/ab-initio/de-novo antimicrobials discovery. New targets for antimicrobials. Rational design of antimicrobials. Bioinformatics and comparative genomics for the identification of antimicrobial targets…
Disinfectants, antiseptics, preservatives… Mechanism of action. Resistance to non-antibiotic biocides. Combination of physical and chemical treatments. Hygiene and Sterilizing. Sanitizers. Regulatory issues. Good practices…
Exploitation of physical properties for killing/inactivating microbes: surface tension (nano-emulsions), radiation, ultrasounds, temperature, specific properties of nano-materials (nano-particles, nano-tubes/wires, nano-crystals, nano-grained materials…). Resistance to physical agents...
Clinical and medical microbiology, infectious diseases and antimicrobials. Public health
Strengthening of innate immune system as antimicrobial strategy:
Immunotherapy, immunomodulating agents, cytokines (interleukins, colony-stimulating factors, interferons…), hormones…
Novel vaccines for preventing or treating disease…
Antimicrobial resistance. Mechanisms of action of antimicrobial agents:
Microbial resistance to antibiotics and biocides. Resistance genes. Prevention of resistance. Surveillance & statistics. Genetics and Proteomics…
Inhibitors of bacterial cell wall biosynthesis. Inhibition of protein biosynthesis. Inhibition of nucleic acid biosynthesis. Alteration of cell membrane function. Inhibition of cell metabolism (antimetabolites).
Superbugs. Multi-resistant strains. Emerging and re-emerging bacteria and fungi in humans, animals, and plants.
Methicillin-resistant Staphylococcus aureus (MRSA), Vancomycin Intermediate/Resistant
Staphylococcus aureus (VISA/VRSA), Clostridium difficile,
Mycobacterium tuberculosis, Vancomycin-resistant
Enterococcus (VRE), Cryptosporidium,
Plasmodium parasites, Plasmodium falciparum, Leishmania species,
Klebsiella pneumoniae, Streptococcus pneumoniae,
Acinetobacter baumannii, Cryptococcus,
Escherichia coli O157:H7, Helicobacter spp.,
Enterobacter sakazakii, Serratia spp.,
Pseudomonas aeruginosa (FQRP)...
Attenuation of virulence as antimicrobial strategy:
Interfering microbe-microbe communication (quorum sensing). New strategies...
Techniques and Methods:
Susceptibility Testing. Rapid microbial and resistance detection. Detection of antibiotics in environmental samples. Microscopy, microanalysis & spectroscopy, single-cell studies, high-throughout studies, nanomechanical studies, microfluidics,
lab-on-a-chip concepts, miniaturized science, analysis of microbial surfaces, heterogeneity, statistics. Interaction of antimicrobial
drugs with model membranes. Analytical techniques…